CRISPR is a unique structure of repeating DNA sequences that are an important part of the immune system of microorganisms (eg, bacteria). CRISPR has the ability in the event of a virus attack to destroy its genome, thereby preventing its spread.
Using this process, scientists have developed a CRISPR-technology, allowing to make changes in the DNA of people, animals and plants. In other words, humanity has come close to the possibility of editing genes.
The Japanese researcher Nureki Osamu together with his colleagues from the University of Tokyo and Kanazawa University for the first time filmed unique footage on the video, where the CRISPR-Cas9 system literally “gnaws” into a segment of DNA in real time.
To remove unique frames it was possible owing to a high-speed microscope in which structure the micromechanical probe-cantilever enters. Its pointed end constantly approaches the surface being examined, then it moves away from it. Changes in cantilever deflections during the operation of the microscope are fixed by the laser and using the computer create the resulting image.
CRISPR-technology was first applied to the removal of the HIV genome in mice and to change the genome of dogs, which allowed the breed to grow with increased muscle mass. As a result of the editing of genes, it was possible to accelerate the growth of crops and create new types of antimicrobial treatment. The film, shot by Japanese scientists, will help to better understand these complicated processes.